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    更新日: 2025.01.22
    Medical information: Ange

    Important safety information including dosage, side effects, and precautions of Ange.

    Indications

    ・Contraception


    ・Oral contraceptives do not protect against HIV infection (AIDS) and other sexually transmitted infections (e.g., syphilis, genital herpes, gonorrhea, chlamydia, genital warts, trichomoniasis, hepatitis B).


    Dosage and Administration

    ◆Ange21


    ・Start taking 1 tablet daily at the same time every day from the first day of your menstrual period for 21 consecutive days, then take a 7-day break.


    ・Repeat this cycle each month, even if your period has not finished.


    ・Take the tablets in the order indicated by the arrows on the blister pack.


    ・Start with the brown tablets (1-6) for 6 days, followed by the white tablets (7-11) for 5 days, and then the yellow tablets (12-21) for 10 days.


    ・Take each tablet with a glass of water or lukewarm water.



    ◆Ange28

    ・Start taking 1 tablet daily at the same time every day from the first day of your menstrual period for 28 consecutive days.


    ・Repeat this cycle each month, even if your period has not finished.


    ・Take the tablets in the order indicated by the arrows on the blister pack.


    ・Start with the brown tablets (1-6) for 6 days, followed by the white tablets (7-11) for 5 days, the yellow tablets (12-21) for 10 days, and then the red tablets (22-28) for 7 days.


    ・Take each tablet with a glass of water or lukewarm water.

    Important points

    ・If you start taking the pill later than the first day of your menstrual period, use an additional contraceptive method for the first week (use another contraceptive method or avoid sexual intercourse for the first 7 days).


    ・Smoking can increase the risk of cardiovascular side effects, especially in women over 35 years old.

    Therefore, please quit smoking while taking this medication.


    ・If you miss 1 tablet (1 day): Take the missed tablet as soon as you remember, then continue taking the tablets at your usual time.

    If you notice that you have missed a tablet and it is almost time for your next dose (e.g., if you usually take the tablet at 8:00 AM and you notice that you have missed the previous day’s tablet at 6:00 AM the next day), take 2 tablets at your usual time.


    ・If you miss 2 tablets (2 consecutive days): If you notice within 2 days, take 2 tablets immediately and then continue taking the tablets at your usual time.

    If you miss 2 days of tablets and it is the 3rd day, there is a possibility of pregnancy, so use an additional contraceptive method until you have taken the tablets continuously for 7 days.


    ・If you miss 3 or more tablets (3 or more consecutive days): You need to start over from the beginning of the cycle. Discard the pack you are currently using, even if there are pills remaining, and start taking a new pack of pills when your next period begins.



    ◆When switching from another oral contraceptive to this product:

    ・If switching from a 21-tablet oral contraceptive: Finish taking all the tablets in the previous pack, take a 7-day break, and then start taking this product.


    ・If switching from a 28-tablet oral contraceptive: Finish taking all the tablets in the previous pack and then start taking this product.


    Main Side Effects

    Blood clots can occur with the use of oral contraceptives, regardless of risk factors such as age, smoking, obesity, or family history.

    If you experience any of the following symptoms, stop taking the medication immediately and consult your doctor.

    ・Sudden pain or swelling in the legs


    ・Sudden shortness of breath, chest pain


    ・Severe headache, weakness or numbness in the arms or legs, difficulty speaking, sudden visual disturbances


    ・If you suspect a blood clot or if your risk of blood clots increases, stop taking the medication immediately, even if the symptoms or condition are mild, and consult your doctor or contact the elife customer support. Other side effects may include nausea, headache, breast tenderness, and spotting.


    ・Spotting is common in about 20% of women who start taking low-dose oral contraceptives. Therefore, spotting is not unusual. If spotting is mild, observe for 2 months after starting to take the medication. If spotting continues for more than 3 months, consult your doctor.


    Contraindications and Precautions

    ・Please consult your doctor if you are using other medications.


    ・When visiting other health care providers, please mention that you are taking this medicine


    ・In case of emergency, such as the appearance of serious side effects, stop taking the medication immediately and seek medical attention at the nearest medical institution.



    ______________________________

    ◆Do not use this medication, or use with caution if you have any of the following conditions. Always consult your doctor.

    ・Age 40 years or older


    ・BMI of 35 or higher


    ・Smokers aged 35 or older who smoke 15 or more cigarettes per day (including electronic cigarettes)


    ・Pregnant, may be pregnant, or breastfeeding


    ・Have given birth within the past month


    ・Diagnosed with high blood pressure (systolic blood pressure 160 mmHg or higher/diastolic blood pressure 100 mmHg or higher)


    ・Have had major surgery in the past 2 weeks or have a scheduled surgery within the next 4 weeks


    Approval status in Japan

    ・Ange is approved in Japan.


    *Medicines prescribed in this department are not covered by the Adverse Reactions Relief System.

    Availability of approved medicines that have the same active ingredients in Japan

    ・In Japan, Labellefille has the same active ingredient as Ange and is approved for the treatment of birth control.

    Means of acquisition

    ・Our affiliated clinic physicians purchase Ange through a domestic pharmaceutical distributor.

    Information on safety and approval in other countries

    ・No serious safety information has been reported in other countries.