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    更新日: 2025.01.22
    Medical information: YazFlex

    Important safety information including dosage, side effects, and precautions of YazFlex.

    Indications

    ・Relief of pain associated with endometriosis


    ・Treatment of dysmenorrhea


    ・Adjustment of the timing of ovarian stimulation in assisted reproductive technology


    Dosage and Administration

    ◆Continuous dosing with a 4-day drug-free interval:

    ・For initial use, take one tablet daily at approximately the same time each day, starting on the first day of your menstrual period.


    ・Continue taking the tablets for 24 days, regardless of bleeding.


    ・If there is no continuous bleeding for 3 days after the 24th day, continue taking the tablets for up to 120 days, then take a 4-day drug-free interval.


    ・If there is continuous bleeding for 3 days after the 24th day, take a 4-day drug-free interval.


    ・Resume taking the tablets on the day following the 4-day drug-free interval.


    ・Repeat this cycle of taking and not taking the tablets.




    ◆28-day cycle (24 days of taking the tablets and a 4-day drug-free interval)

    ・For initial use, take one tablet daily at approximately the same time each day, starting on the first day of your menstrual period.


    ・Continue taking the tablets for 24 days, regardless of bleeding.


    ・Take a 4-day drug-free interval from the 25th to the 28th day.


    ・Resume taking the tablets on the day following the 4-day drug-free interval.


    ・Repeat this cycle of taking and not taking the tablets.


    Important points

    ・The drug-free interval should not exceed 4 days.


    ・Resume taking the tablets after the 4-day drug-free interval, regardless of bleeding.


    ・Continue taking the tablets for 24 days, regardless of bleeding, both when starting the medication and after the drug-free interval.


    ・If you miss one tablet (in one day): As soon as you remember, take the missed tablet right away, and then take your next tablet at the usual time.


    ・If you miss two tablets (in two consecutive days): As soon as you remember, take the missed tablet from the previous day, take your tablet for today at the usual time, and then continue taking the tablets as scheduled.



    ◆When switching from another oral contraceptive:

    ・If you were taking a type with a drug-free interval: Start taking this medication on the day following the drug-free interval.


    ・If you were taking a type with placebo: Start taking this medication on the day after finishing the placebo tablets.


    Main Side Effects

    Thrombosis may occur regardless of risk factors such as age, smoking, obesity, or family history. If you experience any of the following symptoms, immediately stop taking the medication and schedule a follow-up with your doctor:


    ・Sudden pain or swelling in the legs


    ・Sudden shortness of breath


    ・Chest pain


    ・Severe headache


    ・Weakness or paralysis of limbs


    ・Speech difficulties


    ・Acute vision problems


    If symptoms suggestive of thrombosis appear or if you are in a condition that increases the risk of thrombosis, even if symptoms are mild, stop taking the medication immediately and schedule a follow-up with your doctor. Alternatively, contact elife Customer Support.


    Other side effects may include nausea, headache, breast tenderness, and irregular bleeding. Note that approximately 20% of people starting low-dose contraceptive pills may experience irregular bleeding, so this is not uncommon. If irregular bleeding is mild, observe it for two months after starting the medication; if it continues for more than three months, consult your doctor.

    Precautions

    ・Please consult your doctor if you are using other medications.


    ・When visiting other health care providers, please mention that you are taking this medicine


    ・In case of emergency, such as the appearance of serious side effects, stop taking the medication immediately and seek medical attention at the nearest medical institution.



    ______________________________

    ◆Do not use this medication, or use with caution if you have any of the following conditions. Always consult your doctor.



    ・Have or have had blood clots (deep vein thrombosis, pulmonary embolism), stroke, or heart disease


    ・Have unexplained vaginal bleeding


    ・Are over 35 years old and smoke 15 or more cigarettes per day (including electronic cigarettes)


    ・Are pregnant, may become pregnant, or are breastfeeding


    ・Have given birth within the past month


    ・Have been diagnosed with high blood pressure (systolic blood pressure of 160 mmHg or higher, or diastolic blood pressure of 100 mmHg or higher)


    ・Have had major surgery within the past 2 weeks or have a scheduled surgery within the next 4 weeks


    ・Have migraines with aura


    ・Have or have had breast cancer or uterine cancer


    ・Have heart valve disease, diabetes, a blood clotting disorder, or antiphospholipid syndrome


    ・Have a liver tumor or severe liver disease


    ・Have abnormal lipid levels, high blood pressure, or otosclerosis


    ・Have severe kidney disease or acute kidney injury


    ・Have a history of jaundice, persistent itching, or herpes during pregnancy


    ・Have had an allergic reaction to low-dose birth control pills or female hormones


    Approval status in Japan

    ・YazFlex is approved in Japan.


    *Medicines prescribed in this department are not covered by the Adverse Reactions Relief System.

    Availability of approved medicines that have the same active ingredients in Japan

    ・In Japan,　Drospirenone Ethinylestradiol Betadex has the same active ingredient as YazFlex and is approved for the treatment of Dysmenorrhe.

    Means of acquisition

    ・Our affiliated clinic physicians purchase YazFlex through a domestic pharmaceutical distributor.

    Information on safety and approval in other countries

    ・No serious safety information has been reported in other countries.