Weight Control + Anti-Aging

GLP-1 Rybelsus +
Metformin

A daily combination for tackling weight management and supporting health and longevity. In addition to managing blood sugar, it offers a simple, convenient way to stay slim, energized, and feeling your best.

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Why people take Rybelsus + Metformin

Gentle on the body

Higher doses of GLP-1 treatments can lead to more side effects (like nausea or stomach upset). Our low-dose strategy minimizes those risks, while still providing effective results. Research shows that using lower doses of semaglutide is just as effective for weight management, and the side effects are generally mild and transient.

Sustainable in the long term

This combination is designed for maintenance and longevity. Expect steady, gradual weight loss and health improvements that are easier to maintain over time. We've paired the lowest dose of Rybelsus (3 mg) with a mild dose of Metformin (500 mg) to create a sustainable wellness package that delivers results without the major side effects.

Whole-body benefits

By addressing both appetite and metabolic health, you're not just eating less—you're improving how your cells and organs function, leading to better overall wellness.

Important

How to take

To maximize absorption and efficacy, strict timing is essential:

・Rybelsus:

Take immediately upon waking, on an empty stomach, with no more than 120 ml of water. Avoid eating or drinking anything else for at least 30 minutes to ensure proper absorption.

・Metformin:

If you take it in the morning, use it after breakfast to support steady digestion and minimize stomach discomfort. If you take it in the evening, take it with dinner to help maintain consistent blood sugar control and metabolic support overnight.

How it works

Science-backed health benefits

Inhibition of gluconeogenesis via AMPK Activation: Metformin activates AMP-activated protein kinase (AMPK), leading to the inhibition of gluconeogenesis.
Modulation of lipid metabolism: It suppresses triglyceride and cholesterol synthesis while enhancing fatty acid oxidation, resulting in improved lipid profiles.

Findings from mice studies:

Metformin enhances insulin sensitivity and reduces blood LDL-cholesterol, showing metabolic changes similar to those observed with calorie restriction.
It also boosts antioxidant activity, reducing oxidative damage and chronic inflammation.

Development of Anti-aging compounds that Target Potential Aging Control Signaling Pathways

Important

Common side effects

Both medications are generally well-tolerated, but like all prescription drugs, they can have side effects. Most are mild and resolve within a few days.

Rybelsus:

Nausea, stomach pain, diarrhea, decreased appetite, vomiting, and constipation. These often lessen as your body adjusts to the medication.

Metformin:

Diarrhea, nausea/vomiting, and gas or abdominal discomfort. Taking metformin with meals can help minimize these symptoms.